Tretinoin injection cured frozen shoulder, whether it will recur in the future is related to cold, exertion, trauma, functional exercise and so on. Tretinoin injection for the treatment of frozen shoulder has the advantages of simple method, high cure rate and easy outpatient treatment, and is one of the drugs and methods with ideal effect in the clinical treatment of frozen shoulder at present. Mainly, the drug solution is used for pain point closure or bursa injection. Tretinoin injection for the treatment of frozen shoulder generally has a good prognosis, avoiding cold, exertion and trauma is the key to prevent the occurrence and recurrence of frozen shoulder, and the key to the prognosis of frozen shoulder lies in whether or not to carry out functional exercises. It is forbidden for those who are allergic to tretinoin injection, and should be used on balance in patients with severe psychiatric disorders and epilepsy, bone fracture, trauma repair period, recent gastrointestinal anastomosis, corneal ulcer, hypertension, diabetes mellitus, pregnant women, and so on. In addition, weight gain, lower extremity edema, purple lines, easy bleeding tendency, acne, poor wound healing, menstrual disorders, muscle weakness, gastrointestinal irritation (nausea, vomiting) and other adverse reactions can occur during use. It is necessary to use the medication under the supervision of a doctor, not self-medication.