When the kidney disease is in stage 4, usually there will be decreased urine output and edema, accompanied by systemic symptoms such as dizziness, nausea and vomiting, and fatigue. 1. Decreased urine output and edema: the glomerular filtration rate of stage 4 kidney disease is around 15~29ml/min, which is unable to metabolize the waste and excess water in the body quickly, and then decreased urine output and edema will occur. 2. Systemic symptoms: When the waste is circulating in the body, it will cause dizziness, nausea and vomiting, weakness and loss of appetite, which will have serious impact on the health. In stage 4 kidney disease, the kidney function may be permanently damaged, and if no effective treatment measures are taken in time, it will gradually evolve into uremia, which is life-threatening. In this case, it is recommended to prepare for dialysis and take medication as prescribed by the doctor. It is recommended that the patient should consult the hospital in time and follow the doctor’s advice to avoid delaying the condition.