Wine contains a portion of alcohol, and if more wine is added to the cooking, a disulfiram-like reaction can occur when wine and cephalosporin are taken together. Cephalosporin is a general term for cephalosporin antibiotics. Drinking alcohol or consuming large amounts of alcohol-containing food about a week after taking cephalosporin antibiotics can cause a disulfiram-like reaction. Disulfiram-like reaction is a systemic reaction, early manifestations of flushing, rapid heart rate, nausea, dry mouth and other symptoms, severe cases may cause palpitations, chest tightness, blood pressure drop, or even shock leading to death. Disulfiram-like reaction occurs rapidly, once appeared should immediately seek medical attention. In conclusion, it is recommended not to take wine and cephalosporin at the same time, if disulfiram-like reaction occurs, please consult a professional doctor and follow the doctor’s instructions for standardized treatment.