Patients with advanced stage of liver and bile duct cancer have less possibility to be cured, but it is definitely not impossible, as long as they keep positive and optimistic attitude and actively participate in the treatment, there is still a certain possibility to be cured. Hepatobiliary tract cancer can be manifested as progressive aggravation of jaundice, distension and discomfort in the upper abdomen, loss of appetite and emaciation. The overall five-year survival rate of cholangiocarcinoma is still less than 5%. Because most of the cholangiocarcinomas in the advanced stage have distant metastasis or local infiltration, at this time, only comprehensive treatment can prolong the survival of the patients, and the causes of the disease are not particularly clear, which may be related to congenital cystic dilatation of bile ducts due to cholangiocarcinoma stones, primary sclerosing cholangitis and so on. It is hoped that patients can cooperate with doctors to actively carry out comprehensive treatment, keep a positive and optimistic attitude, and believe that miracles will always happen.