The sudden coldness and shivering in the middle of the night may be caused by high fever. If you have a viral cold, you may have a fever at the beginning of the cold, and if your body temperature is too high, it may cause you to feel cold and chills. In addition, there are some cold symptoms, such as sneezing, runny nose, nasal congestion and other symptoms, in this case, we should pay attention to measuring body temperature, if the temperature exceeds 38.5 degrees Celsius, you can take oral antipyretic and analgesic drugs such as ibuprofen to reduce body temperature. If accompanied by other cold symptoms, you also need to take some oral anti-cold medication for treatment to relieve the symptoms of cold. In addition, bacterial infection may also cause symptoms of high fever and chills, so you need to go to the hospital to check the blood routine, C-reactive protein, etc., to see if there is a bacterial infection, if there is a clear bacterial infection, you need to apply antibiotics scientifically and standardized under the guidance of the doctor to carry out anti-infection treatment.