Definition of dry syndrome: It is a chronic inflammatory autoimmune disease with systemic exocrine gland involvement, which can cause damage to several systems such as respiratory, digestive, neurological, and urinary. The incidence of this disease is high, and it is more common in women. Common clinical manifestations of dry syndrome: 1. Dry mouth: frequent drinking is required, and soup is needed to swallow dry food; 50% of patients have flaky tooth loss and blackening, eventually leaving only residual roots, called rampant dental caries; about 50% of patients have recurrent parotid gland enlargement, dry and cracked tongue. 2.Dry eyes: photophobia, foreign body sensation, desire to cry, recurrent conjunctivitis, keratitis, and in severe cases, corneal ulceration. 3.Systemic manifestations: joint swelling and pain, skin nodular erythema, hypokalemia, renal tubular acidosis, interstitial lung lesions, neurological damage, hematological system damage, self-exempt liver disease and other multi-systemic lesions. What is the prognosis of dry syndrome? The prognosis of this disease is good. Most of the cases with internal organ damage can be controlled after proper treatment. If the treatment is not timely, the condition may deteriorate or even endanger the life. Among the visceral damage, those with progressive pulmonary fibrosis, central neuropathy, glomerular damage with renal insufficiency and malignant lymphoma have a poor prognosis; for the rest with systemic damage, most of them can be in remission and resume normal life and work after proper treatment.