Treatment of secondary plasma cell leukemia includes general treatment, drug treatment, chemotherapy and bone marrow transplantation. 1. General treatment: pay attention to light diet and balanced nutrition. If the hemoglobin of the patient is obviously reduced, red blood cells can be transfused to alleviate the condition. 2. Drug therapy: use anti-tumor drugs such as melphalan, which can be used alone or in combination with chemotherapy drugs. 3. Chemotherapy: chemotherapeutic drugs such as cytarabine, cyclophosphamide, and flexerodine can be used in the treatment of secondary plasma cell leukemia, and their combined use can reduce the resistance phenomenon of chemotherapeutic drugs. 4. Bone marrow transplantation: such as autologous hematopoietic stem cell transplantation, which can improve the quality of survival of patients, is generally used as a consolidation therapy. Due to different primary diseases, there are differences in treatment. In addition to the above methods, patients should be actively treated for primary diseases, and plasma exchange and hemodialysis can be carried out if necessary. Antiinfective treatment with antibiotics such as amoxicillin should also be used when accompanied by infection. Secondary plasma cell leukemia is recommended to be treated under the guidance of a doctor. All of the above drugs should be used rationally under the guidance of doctors, avoid self-medication.