Whether a case of squamous cell carcinoma is serious or not should be judged based on the specific stage, differentiation and clinical manifestations of squamous cell carcinoma. When early stage squamous cell carcinoma does not produce serious symptoms, measures can generally be taken to improve the situation. For patients with intermediate and advanced stages, the disease is more complicated and more difficult to treat, and the situation may be more serious. Squamous cell carcinoma occurs in various areas, such as skin, oral cavity, vagina, bronchus, bladder and renal pelvis. For early stage squamous cell carcinoma, the situation is generally not serious, the differentiation degree is higher, the lesion is more limited, the tumor is smaller, regional lymph node metastasis and distant metastasis have not occurred, the damage is lighter, the primary lesion can be removed through extended suppression surgery, the prognosis is better, and can even achieve the effect of cure. For patients in the middle and late stage, the situation is more serious, the differentiation degree of cancer cells is lower, the lesion has invaded the muscle and bone, and even distant metastasis has occurred, so surgery should be taken in time, and post-operative adjuvant treatment with chemotherapy, radiotherapy, targeted drug therapy and immunotherapy can only improve the clinical symptoms and prolong the survival of patients, but not completely cure. Therefore, whether squamous cell carcinoma is serious or not should be analyzed comprehensively. For early stage patients, they should be treated actively to avoid deterioration. For patients in middle and late stages, comprehensive treatment can be used to try to relieve patients’ uncomfortable symptoms, improve patients’ life quality and prolong life.