Red pimples on both sides of the cheeks are generally referred to as acne medically. Common causes include endocrine disorders, abnormal keratinization of the cells around the hair follicles, and over proliferation of Propionibacterium acnes. 1. Endocrine disorders: androgen secretion during puberty, or hyperandrogenemia caused by various other reasons, can make the sebaceous glands hypersecretion, sebum excretion is impeded, resulting in sebum retention, which leads to red pimples on both sides of the cheeks. 2. Abnormal keratinization of cells around hair follicles: this can cause the opening of the hair follicle to become smaller, narrower, or even blocked, which can lead to sebum stagnation and obstruction of sebum excretion, further inducing or aggravating the symptoms of acne. 3. Excessive proliferation of Propionibacterium acnes: these bacteria live in the hair follicles, and when certain factors induce their excessive proliferation, they can cause inflammatory reactions around the hair follicles, excessive keratinization of the sebaceous gland openings, and clogging of the openings, which leads to the emergence of red pimples on both sides of the cheeks. Red pimples on both sides of the cheeks are usually caused by one or more of the above reasons. In your daily life, you should pay attention to avoid squeezing pimples, eat a light diet, and avoid a diet high in sugar and fat. Ensure sufficient rest, do not stay up late. Under the guidance of a doctor, you can use topical retinoic acid cream, clindamycin gel, benzoyl peroxide cream and so on for treatment, the use of medication should follow the doctor’s instructions.