1.Single solid nodule or mass larger than 1 cm in size. 2, Regardless of size, single or multiple solid nodules or masses, ultrasound suggests irregular boundaries, strong echogenic calcification sign or abundant blood flow; mammography suggests burr sign or gravel-like calcification. 3.Long-term single or multiple small nodules or lumps with no change or shrinkage by conservative drug treatment, or increasing in size during treatment and with the above signs on examination. 4.Family history of breast cancer, long-term exposure to radiation in the chest, recent appearance of breast nodules or lumps after menopause; previous surgical treatment of breast cancer on the opposite side and now nodules appear in the breast, nodules or lumps appear again after removal of benign breast hyperplasia or fibroadenoma; nodules or lumps with atypical hyperplasia on puncture. 5, There are more obvious nodules or lumps before preparing for pregnancy and delivery. 6.Single or multiple cysts of the breast exceeding 2-3 cm. 7, Nipple overflow found by examination with small nodules or masses under the areola.