Meningiomas in the region of the foramen magnum of the occipital bone are usually very serious, and due to the location of the growth are difficult to operate on and can easily compress the central nervous system in a life-threatening way. Meningiomas of the greater occipital foramen magnum, also known as foramen magnum meningiomas, are usually referred to as meningiomas that occur around the foramen magnum and usually in front of the foramen magnum. It usually grows into the skull or cervical canal and can lead to compression of the medulla oblongata. Damage to the vital centers is often life-threatening. Meningiomas in the region of the occipital foramen magnum may present with balance dysfunction, limb paralysis, swallowing disorders, and possible loss of bladder or bowel control. Typical presentations of patients are usually persistent pain in the occipital neck, unilateral numbness in the upper limbs, loss of sensation in the contralateral side, progressive muscle weakness starting from the upper limbs with muscle atrophy in the hands, and may present with unsteady walking, ataxia, and nystagmus. Meningioma in the region of occipital foramen magnum can be treated by surgery, which is risky, and radiotherapy is needed if there is any residual tumor after surgery. Meningioma in the region of the occipital foramen magnum needs timely medical treatment, standardized treatment, to avoid delaying the condition.