The differences between ofloxacin and levofloxacin are different composition, different antibacterial strength, different antibacterial spectrum, and the rest are basically the same. 1. Different composition: the main component of ofloxacin is ofloxacin; the main component of levofloxacin is levofloxacin, which is the levorotatory ofloxacin. 2. Different antibacterial strength: the antibacterial strength of levofloxacin is stronger than that of of ofloxacin, and the antibacterial strength of levofloxacin can be twice that of of ofloxacin. 3. Different antibacterial spectrum: Ofloxacin is used for respiratory tract infections, genitourinary tract infections, gastrointestinal tract infections, skin and soft tissue infections, etc. caused by sensitive bacteria; Levofloxacin is not only suitable for the above infections caused by sensitive gram-negative and gram-positive bacteria, but also used for infections of stomatology, otorhinolaryngology, ophthalmology, dermatology, etc., and urethritis and cervicitis caused by gonococcus and chlamydia trachomatis. Ofloxacin and levofloxacin are quinolone antimicrobials, and their indications, adverse reactions and contraindications are basically the same. Adverse reactions include gastrointestinal discomfort, allergic reactions, liver function abnormalities, mental abnormalities, etc. It is contraindicated for those who have a history of allergy to quinolone antibacterial drugs, pregnant and lactating women, children, and patients under 18 years old. Doctors should choose the appropriate drugs for use according to the specific conditions of the patient, pay attention to the therapeutic effect and adverse reactions during the use of drugs, and consult a doctor in time when discomfort occurs.