Atrial septal defect fast heart rate can be given to control the heart rate of drugs, such as the combination of infection can be used antibiotics to control infection, there are indications for surgery should be early surgical treatment. Patients with atrial septal defect will have cardiac insufficiency, cardiac insufficiency will lead to hypoxia, hypoxia will occur after compensatory heart rate acceleration, based on the control of heart failure, can be given to control the heart rate of metoprolol and other drugs treatment. Patients with atrial fibrillation who develop accelerated heart rate can be treated with drugs such as cediran and amiodarone. Patients with atrial septal defect, some of them may be accompanied by lung infection, after the lung infection, patients will have hypoxia, at the same time can be accompanied by symptoms of fever, also will have a rapid heart rate, the treatment should pay attention to the anti-infection treatment, commonly used drugs are penicillin, cefozoxime and so on. Patients with atrial septal defect, if there is an indication for surgery, early surgical treatment, can also improve the patient’s symptoms to control the heart rate. Patients with atrial septal defects should go to the hospital, evaluate their condition under the guidance of the doctor, and use medication under the doctor’s supervision.