The normal range of blood pressure differential, i.e. pulse pressure (difference between systolic and diastolic blood pressure) is 30-40 mmHg. Pulse pressure of 50 mmHg is slightly higher than the normal range, which can be considered as hyperthyroidism, aortic valve closure insufficiency and arteriosclerosis. 1. Hyperthyroidism: the patient’s metabolism increases, blood flow increases, systolic blood pressure increases, resulting in increased pulse pressure. 2. Aortic valve insufficiency: the patient’s diastolic blood regurgitates to the left ventricle and the diastolic pressure decreases, leading to an increase in pulse pressure. 3. Atherosclerosis: the patient’s arterial elastic reserve capacity is reduced, resulting in higher systolic pressure, lower diastolic pressure and higher pulse pressure. The appearance of high pulse pressure should be timely to the hospital, under the guidance of professional doctors to receive standardized treatment.