The difference between chalazion and granuloma generally lies in the different causes, clinical symptoms and treatment modalities. 1. Causes: chalazion is usually caused by bacterial infection in the eyelid area due to lack of attention to eye hygiene, etc.; chalazion is usually caused by excessive secretion of oil in the blepharoplakic gland area, which blocks the outlet of the blepharoplakic gland and causes cysts. 2. Clinical symptoms: chalazion may appear in the eyelid hard lumps, and the symptoms of mobile; granuloma usually appear in the eyelid redness, swelling, pain and other symptoms. 3. Treatment: Chalazion can be treated with medicines such as gentamycin hydrochloride ophthalmic ointment and compound sulfamethoxazole sodium eye drops under doctor’s guidance, and surgical treatment if necessary; for chalazion with serious condition, surgical excision is needed for treatment. Chalazion and granuloma belong to two different diseases, it is recommended that patients under the diagnosis of the doctor, clear specific diseases and causes for standardized treatment.