Anti-SSA antibodies are also known as anti-RO antibodies, and the clinical significance of positive anti-SSA antibodies is mainly used to help diagnose desiccation syndrome. In primary dry syndrome, the positive rate of SSA antibodies accounts for about 40%-95%. Anti-SSA antibody positivity can also be seen in rheumatoid arthritis, systemic lupus erythematosus, scleroderma, primary biliary cirrhosis, subacute cutaneous lupus erythematosus, neonatal lupus syndrome, dermatomyositis and other diseases, which account for a relatively small proportion. Occasionally seen in chronic active hepatitis, anti-SSA antibodies are involved in histopathological damage, especially in the skin, and can cause subacute cutaneous lupus erythematosus, associated with the photoallergic phenomenon of SLE. patients with primary dry syndrome who are positive for SSA antibodies are more likely to have extra-glandular manifestations, such as vasculitis, lymphadenopathy, and anemia, than those who are negative for antibodies. Rheumatoid factor is also mostly positive.