Whiteheads on the face usually refer to pimples, which is one of the clinical manifestations of acne. The darkening of whiteheads and the appearance of subcutaneous nodules may be due to aggravation of the condition. Due to the abnormal keratinization of local cells around the skin, it can lead to the follicle opening becoming smaller, narrower and blocked, sebum can not be discharged normally, and accumulates in the follicle opening to form pimples, which are mild acne. As the condition progresses, if the patient stays up late at night, is emotionally stressed, or eats spicy and greasy food, it can lead to excessive sebum secretion, and the fatty acids in sebum are suitable for the growth and reproduction of Propionibacterium acnes, which increases the number of Propionibacterium acnes, leading to inflammation of the tissues around the hair follicles and their destruction, aggravating acne, and ultimately forming nodules and cysts, which can leave behind scarring after breaking. When acne appears, don’t often touch or squeeze it with your hands to avoid causing infection and aggravation of the condition. When acne turns black and subcutaneous nodules appear, it is recommended to consult a doctor for further examination and targeted treatment or therapy with the help of a doctor.