Closed acne is a chronic inflammatory skin condition that occurs in the sebaceous glands of the skin follicles and manifests itself as pinhead-sized, creamy-white papules on the surface of the skin. Closed acne can be removed by medication, chemotherapy and physical therapy. 1. Medication: Local topical retinoic acid drugs such as retinoic acid cream and adapalene gel can be used to dissolve microcomedones and pimples and anti-inflammatory effects, all of the above drugs have adverse reactions and are recommended to be used under the guidance of a doctor. 2. Chemical treatment: chemical treatment such as acid resurfacing, fruit acid resurfacing is the use of a high concentration of fruit acids, can effectively improve the epidermis abnormal keratinization and skin oil excretion, so as to remove acne, suitable for patients with mild symptoms. 3. Physical therapy: Physical therapy, such as photodynamic therapy, can inhibit sebum secretion, but also improve the follicle mouth keratinocyte hyperkeratosis, generally applicable to closed acne progress aggravated by scarring of patients with moderate to severe conditions. There are more treatment methods for closed acne, so it is recommended to visit the hospital in time and be treated under the guidance of the doctor.