The common causes of shoulder pain and waking up from sleep at night include frozen shoulder, angina, periarticular shoulder diseases, neck and shoulder tumors, and so on. 1. Frozen shoulder: it refers to the chronic injury inflammation of periapical region, tendon, muscle, bursa and joint capsule, which is common in people around 50 years old, with clinical manifestations of active pain and limitation of shoulder abduction, external rotation and extension, and in serious cases, moving the shoulder at night can cause pain affecting sleep. 2. Angina pectoris: it can occur in sleep or quiet state, mainly manifested as chest pressure pain, often accompanied by chest tightness, pallor, profuse sweating, etc., and some patients can be accompanied by radiating pain from shoulder to left upper limb. 3. Peri-shoulder diseases: including impingement syndrome, rotator cuff injury, etc., the affected limb can cause shoulder joint pain when lifting, and sometimes patients can wake up from sleep with pain. 4. Neck and shoulder tumors: neck and shoulder tumors may also compress the local muscles or nerves, with the progress of the disease, the local pain will be aggravated, and there will be shoulder pain in a quiet state, and the phenomenon of waking up at night with pain. Shoulder pain waking up at night may also have other causes, such as ankylosing spondylitis, neck and shoulder herpes zoster, etc. It is recommended to consult a doctor in a timely manner, improve the relevant examination, and carry out targeted treatment.