When mandibular cancer develops into advanced stage, surgical treatment, chemotherapy and radiation therapy need to be considered to deal with it actively. 1. Surgical treatment: mandibular cancer may damage the mandibular tissues and affect the normal occlusal function, so the local diseased tissues can be scraped clean, and then autologous iliac bone transplantation can be carried out, which can improve the quality of life of the patients. 2. Chemotherapy: after surgical treatment, cisplatin, cyclophosphamide, methotrexate and other drugs should be used to inhibit the growth and reproduction of tumor cells as prescribed by doctors. 3. Radiation therapy: corresponding ray irradiation to the diseased part of jawbone can also effectively prevent tumor recurrence in the late stage, and the method of multiple irradiation with small dose of ray can be adopted. The above are the main treatment methods for advanced mandibular cancer, which need to be correctly treated under the guidance of doctors and keep a good mindset so as to have a better prognosis.