Vomiting and stomach pain in the middle of the night in children may be associated with acute gastroenteritis, acute appendicitis, and intestinal obstruction, which may be given non-surgical or surgical treatment. Children vomiting in the middle of the night, stomach pain is related to the following factors: 1. Acute gastroenteritis: bed rest, get rid of the cause, correct water loss and electrolyte disorders. If the bacterial infection, can be given oral such as cefixime and other antibacterial drugs for treatment. If the infection is viral, it is self-limiting and can be treated without special medication. Oral rehydration salts can be given to prevent dehydration in case of severe vomiting. 2. Acute appendicitis: oral antibiotics (e.g. cefixime) can be given according to the condition, or surgical treatment to remove the appendix. 3. Intestinal obstruction: saline, amino acids, potassium chloride, etc. can be given to regulate the water-electrolyte balance, prevention and treatment of infection and other non-surgical treatments, if necessary, feasible surgical treatment. Children vomiting in the middle of the night, stomach pain is recommended to consult a doctor in a timely manner, improve the relevant examination, after a clear diagnosis under the guidance of the doctor’s treatment. The above medications should be used under the guidance of a doctor.