Stomach pain at night may be related to physiological reasons such as consuming a large amount of food, or pathological reasons such as gastritis. 1. Physiological reasons: If you consume a lot of food at night, especially spicy and stimulating and indigestible food, which leads to gastrointestinal indigestion, you will be prone to stomach pain. 2. Pathologic causes (1) Gastritis: Inflammation of the stomach can be manifested as nocturnal pain, located in a certain position in the epigastric region, and recurrent pain can occur. (2) duodenal ulcer: secretion of a large amount of gastric acid at night, when the secretion of gastric acid is not mixed with food, into the duodenum directly stimulate the ulcer site of the nociceptive nerve endings, thus causing severe epigastric pain. (3) Gastroesophageal reflux disease (GERD): when lying down at night, the gastric reflux increases, which can directly stimulate the esophageal mucosa, thus leading to epigastric pain. In addition, there are other reasons that can lead to stomach pain at night, if recurring or severe symptoms, it is recommended to go to a regular hospital in time, under the guidance of the doctor to carry out targeted treatment, in order to reduce the adverse effects of the disease.