88 years old elderly lumbar vertebral body uneven bone density, the possible causes of osteoporosis, degenerative osteoarthritis, etc., if there is no obvious discomfort, may not be treated, such as osteoporosis need to supplement calcium treatment. 1. Osteoporosis: uneven bone density of lumbar vertebrae in imaging report of middle-aged and old people is mostly caused by osteoporosis. Generally need to take calcium tablets and vitamin D combined treatment. It should be noted that excessive use of calcium tablets may appear high blood calcium, excessive use of vitamin D may appear digestive discomfort, high fever and other adverse reactions. 2. Degenerative osteoarthritis: When there is serious degeneration of the vertebrae, it may lead to degenerative osteoarthritis and uneven bone density. If combined with pain, non-steroidal anti-inflammatory drugs such as aspirin can be given for anti-inflammatory and analgesic treatment, and at the same time oral nutrition of cartilage such as glucosamine hydrochloride tablets. Elderly people with lumbar vertebrae uneven bone density should pay attention to rest, and it is recommended to go to the regular hospital in time to find out the cause, according to the doctor’s advice for treatment.