Uneven thickness of the pulmonary arteries in the right apical portion of the lungs is usually characterized by uneven narrowing of the pulmonary arteries and uneven thickness of the arteries. The pulmonary texture consists mainly of the pulmonary arteries, pulmonary veins, bronchi and lymphatics. Uneven thickness of the pulmonary arteries is usually caused by pulmonary hypertension, which is characterized by symptoms such as dyspnea and fatigue. Uneven thickness of the pulmonary arteries in the apical portion of the right lung can be treated with medications such as Iloprost on the advice of a doctor. In severe cases, surgery such as lung transplantation can be performed. In daily life, one should pay attention to a balanced diet, eat fresh fruits and vegetables, and avoid spicy and irritating foods. Meanwhile, pregnancy, cold and strenuous exercise should be avoided to avoid aggravating pulmonary hypertension. If the patient has uneven thickness of the pulmonary artery in the right apical part of the lung, he/she should go to the hospital in time and take effective treatment under the doctor’s guidance.