Positive 2019-nCoV nucleic acid (novel coronavirus) was detected in the stool of some patients with confirmed novel coronavirus infection with pneumonia, which is likely to suggest the presence of live virus in the stool. After observing that the first symptom of some patients with novel coronavirus pneumonia was only diarrhea, Wuhan University People’s Hospital suspected that the digestive system might also be the transmission route of the new coronavirus. Later, relevant tests at the Wuhan Institute of Virology, Chinese Academy of Sciences, confirmed that viral nucleic acids were also found in the stool and anal swabs of these patients. The research team accordingly proposed that, on top of the droplet transmission and contact transmission proposed in the previous national authoritative guidelines, there is also a certain fecal-oral transmission of neo-coronavirus. The fecal-oral route refers to the mode of transmission of infectious diseases, also known as transmission via the gastrointestinal tract. The pathogens of some infectious diseases can survive in the stool, so they can be transmitted through the stool excreted in the digestive tract. If this pathogen-bearing stool contaminates hands or food, then the disease can enter through the mouth, leading to transmission to others. Clinicians, especially gastroenterologists, should pay close attention to the atypical symptoms of neoconiosis and provide personal protection for patients with vomit and feces. When isolating mildly ill patients at home, extra attention should be paid to personal and family member hand hygiene, while avoiding sharing bathrooms with family members whenever possible. If there is no separate bathroom, home isolation disinfection can be done after each use through disinfectants such as ether, 75% ethanol, chlorinated disinfectants, peroxyacetic acid and chloroform and other lipid solvents that can effectively inactivate the new coronavirus. Daily cleaning and preventive disinfection 1. Object surfaces: For frequently touched surfaces such as countertops, door handles, switches, sinks, toilets, etc., chlorine-containing disinfectants (effective chlorine concentration 250 mg/L-500 mg/L) can be wiped for 30 min, and then wiped with water. 2.Ground: Use chlorine-containing disinfectant (effective chlorine concentration 250 mg/L-500 mg/L) and wipe with a wet mop for 30 min, then wash with clean water. 3.Common fabrics: Use chlorine-containing disinfectant (effective chlorine concentration 250 mg/L-500 mg/L) for towels, etc., soak for 30min, then rinse with clean water. Common disinfectant usage 1.Chlorine disinfectant with effective chlorine concentration 500 mg/L: 84 disinfectant solution (effective chlorine content 5%): diluted by 1:100 ratio of disinfectant solution: water; disinfectant powder (effective chlorine content 12-13%, 20g/pack): 1 packet of disinfectant powder plus 4.8 liters of water; chlorine-containing effervescent tablets (effective chlorine content 480mg/tablet-580mg/tablet): 1 tablet dissolved in 1 liter of water. tablet dissolved in 1 liter of water. 2.75% ethanol disinfectant solution: use directly. 3.Other disinfectants are prepared and used according to the concentration of the product label to kill intestinal pathogenic bacteria. Precautions: 1. Chlorinated disinfectants are irritating to skin mucous membranes, so it is recommended to wear masks and gloves when configuring and using. 2. Ethanol disinfectant should be used away from fire sources. Source: Shenzhen Health Care Commission Wuhan University People’s Hospital Zhuhai High-tech Zone