Stage IV colon cancer also refers to advanced colon cancer, which generally refers to distant metastasis, such as liver metastasis or lung metastasis, peritoneal metastasis, etc. The overall survival period is relatively low, and the 5-year survival rate is about 10%. After the diagnosis of advanced colon cancer is clear, it is recommended to adopt translational therapy, that is, chemotherapy or targeted therapy first, combined with radiotherapy when necessary. Generally, after 2-3 courses of translational therapy, enhanced CT or MRI will be done again to re-evaluate whether there is any chance of surgery. Depending on the situation of liver metastasis, the tumor can be resected in the first stage or in the second stage. For the treatment of liver metastasis of colon cancer, if it is more aggressive, the survival rate can reach 5 years, and the better one can reach about 30%.