A slightly widened hepatic cleft is a widening of the original natural gap between the lobes of the liver and other neighboring lobes of the liver, and is mainly seen in diseases that manifest a reduction in the size of the liver. Hepatic cleft refers to the natural gap in the Glisson’s system contained in the liver, and widening of the hepatic cleft is most commonly seen in diseases such as cirrhosis and fibrosis, which manifest as atrophy of the liver and imbalance of the proportions of the liver lobes. Diseases that may present with a slightly wider hepatic cleft can be diagnosed and differentiated with the aid of liver tests, imaging tests such as CT, ultrasound, and portal pressure measurements. Patients may also have digestive disorders, bleeding tendencies, portal hypertension, etc. Patients with slightly widened hepatic fissure should consult the relevant regular hospitals in time, identify the primary disease, actively carry out standardized treatment, regular follow-up, and maintain a healthy lifestyle.