Several international studies in recent years have shown that preventive interventions for the three highs should be advanced in order to prevent damage to vital organs such as the heart, brain and kidneys. Specifically we should start to act actively from the pre-hypertension, the pre-diabetes and the hypercholesterolemia in low risk groups. Knowing this mystery, we often get twice the result with half the effort, otherwise we will pay the price of high OO due to ignorance. Preventive measures for the three highs have commonalities as well as individuality. Usually start with lifestyle changes, lifestyle changes are common to the three highs, including: 1, stop smoking; 2, lose weight; 3, drink a small amount of alcohol; 4, physical exercise (moderate exercise greater than or equal to 30 minutes per day); 5, low salt (less than 2.4 grams per day); 6, increase fruits and vegetables, reduce the amount of total fat, reduce saturated fat intake; 7, increase omega-3 fatty acids. Pharmacological interventions should be considered only when lifestyle interventions are not effective. For the prevention of hypertension, there was a trial using the antihypertensive drug candesartan orally, and after 2 years the number of people who developed hypertension was reduced by two-thirds compared to the control group, but the effect disappeared soon after stopping the drug. It is still practical to promote lifestyle changes to fundamentally eradicate environmental factors that lead to hypertension. Lifestyle interventions for diabetes, mainly diet and exercise, can reduce the occurrence of type 2 diabetes by 43%. Pharmacological interventions for diabetes include metformin, acarbose and rosiglitazone. More international studies have shown that lowering cholesterol, especially LDL, can reduce new or recurrent coronary heart disease by 20-40%. Low-risk groups have also shown significant results with only half the usual dose of statins. Since the pre-triglycerides often have no clinical symptoms and appear to be robust, the organs in the body are quietly changing. By the time complications such as myocardial infarction, stroke or uremia occur, it will be too late.