Side effects from long-term application of imiquimod cream, i.e. adverse reactions, are often manifested as local skin reactions and systemic symptoms. 1. Local skin reactions: long-term application of imiquimod cream may cause local erythema, edema, erosion, burning sensation, pain, itching, flaking and other adverse reactions. 2. Systemic symptoms: long-term use of the drug, the drug may also be absorbed percutaneously into the blood, causing systemic adverse reactions, may appear fatigue, fever, flu-like symptoms, etc., may also cause headache, diarrhea, myalgia and other symptoms. Long-term application of imiquimod cream if an adverse reaction occurs, it is recommended to stop the drug in time to avoid the adverse reaction to continue to develop. Patients who are allergic to this product are prohibited. Patients need to use this product under the supervision of a physician. Long-term application of imiquimod cream if adverse reactions occur, you need to stop the drug immediately, and promptly contact the attending physician, while patients are advised not to self-medicate to avoid serious adverse reactions.