Clinically there are no five major diseases of night coughing, but night coughing needs to be alert to asthma, tuberculosis, gastroesophageal reflux disease and other diseases. 1. asthma: asthma, especially cough variant asthma, will appear at night episodes of coughing, and airway hyperresponsiveness. 2. Tuberculosis: Cough is a common symptom of tuberculosis, which can occur at night, usually dry, and is accompanied by symptoms of tuberculosis poisoning, such as fatigue and night sweats. 3. Gastroesophageal Reflux Disease (GERD): GERD refers to the reflux of gastric acid into the esophagus and throat at night, especially after eating before going to bed, which may cause coughing at night. In addition to this, nighttime coughing may also be caused by other diseases such as bronchitis, lung abscess, lung cancer, heart failure, and reflux of secretions from rhinitis or sinusitis. When coughing frequently at night and accompanied by other uncomfortable symptoms, you should go to the hospital in time, to clarify the cause of the disease and under the guidance of the doctor for treatment.