A nose that feels grainy and rough to the touch can be associated with conditions such as improper cleaning, nose allergies, rosacea, and acne. It needs to be clearly diagnosed and relieved by general treatment and medication. 1. Improper cleansing: If the patient does not pay attention to the cleansing of the nose area for a long time, sebaceous glands and dirt will accumulate, which will lead to rough skin. Patients should pay attention to the cleanliness of the nose area, and can use mild cleanser to clean. 2. Nose allergy: if contact with pollen or animal hair and other substances, may cause allergic reactions, will be accompanied by itching symptoms. Cetirizine hydrochloride tablets, vitamin C tablets, desloratadine tablets and other medications can be taken orally. 3. Rosacea: Patients with rosacea will have pimple-like granules on the nose and red spots. It can be treated with drugs such as Brimonidine Tartrate Gel and Erythromycin Ointment. 4. Acne: If the patient’s nose sebaceous gland secretion is too exuberant, it may cause acne. You can apply adapalene gel, azelaic acid cream medication. The patient is best to consult a doctor in a timely manner, a clear diagnosis, strictly comply with the doctor’s instructions for the appropriate conditioning treatment.