Pre-uremic reactions are mainly nausea, loss of appetite, pale skin, generalized weakness, increased nocturia and so on. Uremia is the end stage of the development of chronic renal failure, and the pre-stage is also called the early stage of uremia. Patients in this stage may not have severe gastrointestinal symptoms such as repeated vomiting, but there have been relatively mild gastrointestinal symptoms, such as loss of appetite, do not want to eat anything you see, and there will be a slight nausea after eating, these are toxins, especially urea nitrogen in the gastrointestinal tract in the accumulation of the results. This stage of the patient has a mild to moderate anemia, anemia patients will be manifested as pale skin, and at the same time in the activities will feel weak, no energy. This phase of the patient more nocturia, a night can reach more than 5 times, and each time the amount of urine are more, this is a typical increase in nocturia, the main reason is that patients with uremia in the early tubular concentration dysfunction, for the concentration of urine is relatively poor, the night urination is more.