Parkinson’s disease is a chronic condition that requires long-term treatment. Medications are one of the main treatments for Parkinson’s disease, and almost all Parkinson’s patients need to take medication. Although Parkinson’s medications have relatively few short-term side effects, there are still many potential problems with long-term application. How to get the best possible outcome and the lowest possible side effects during Parkinson’s disease treatment is difficult to achieve with just one drug, especially for patients with progressive Parkinson’s disease. Patients often struggle with which medication is better to choose. Taking just one drug often requires larger doses to achieve better outcomes, which also has more side effects. A more reasonable approach to taking anti-Parkinson’s disease is to reasonably combine 2 or more anti-Parkinson’s medications, with the specific method of application to the patient’s specific condition. For example, if amantadine is more effective for muscle tonicity and dopamine agonists are more effective for tremor, then the two drugs can be used in combination, both in smaller doses, with complementary efficacy and reduced adverse effects. As the disease progresses, if amantadine is not effective for tonicity, a small dose of levodopa preparation can be substituted for amantadine, still taking the dopamine agonist. Drug combinations are applied in more combinations and need to be developed by a specialist according to the patient’s specific condition and adjusted in time for practical application.