Plantar hard nodules may be due to callus, metatarsal warts, tinea pedis and other conditions, patients need to follow the doctor’s instructions for drug treatment, general measures. 1. callus: usually patients often appear skin thickening, rough symptoms, and also appear in the skin hard bulge, mostly in the palm of the hand, the soles of the feet and other parts of the foot, which can be manifested as plantar hard lump nodules. The situation generally does not require treatment, patients in the local friction to reduce the majority of patients can be relieved on their own. However, if the stratum corneum is too thick and hard and affects your daily life, you can remove the thickened stratum corneum with a knife, or you can use medication such as salicylic acid cream or retinoic acid cream under the guidance of a doctor. 2. metatarsal warts: usually can occur in any part of the soles of the feet, most of them will appear small, shiny papules, border clear, surrounded by thickened keratin ring, some patients can also be manifested in the soles of the feet of the hard nodules. Some patients can disappear on their own without special treatment, but the pain is obvious and the lesions are multiple, active treatment is also needed. Patients need to follow the doctor’s instructions for external use of 5% fluorouracil soft, 5% imiquimod ointment, etc., can also be injected into the skin lesions of pingyangmycin, bleomycin, etc.. And some patients can also with oral cimetidine, zinc sulfate and other immunomodulators. 3. Tinea pedis: general blister type tinea pedis will be manifested in groups or scattered distribution of small blisters, blister wall is not easy to break, will be accompanied by itching symptoms, which can also appear on the soles of the feet of the phenomenon of hard lumps and nodules. Patients need to follow the doctor’s instructions for local use of ketoconazole, terbinafine and other antifungal drugs, but also with the use of salicylic acid and other exfoliators for treatment. It is recommended that patients with plantar nodules actively seek medical treatment.