The main side effects of metformin are gastrointestinal reactions such as nausea and diarrhea. How can you apply it to reduce its side effects? 1, If possible, do not take it on an empty stomach or before meals, take it during meals. The absorption of the drug is not affected, and adverse reactions are significantly reduced. Tablets that are enteric-coated can be taken before meals. Those who have just started taking metformin can take the drug once with dinner during the first week. 2, adverse reactions are often related to the dose, so you should start with a small dose (500 mg / day), and then you can gradually increase the dose, so that the gastrointestinal tract slowly adapt. The daily dosage should preferably not exceed 2 grams. 3, the use of special dosage forms: such as enteric-coated tablets, extended-release tablets. These dosage forms cause fewer gastrointestinal adverse reactions. Enteric-coated tablets: disintegrate in the small intestine, high bioavailability, reduce gastrointestinal stimulation, half an hour before meals to take the therapeutic effect is better. Extended-release tablets: can be taken once a day to help slow down gastrointestinal side effects of. If the side effects cannot be effectively minimized, the drug should no longer be used and insulin treatment can be considered.