High blood pressure taking Irbesartan Hydrochlorothiazide Tablets can be replaced with Amlodipine Benzenesulfonate Tablets. Irbesartan Hydrochlorothiazide Tablets is a combination antihypertensive drug composed of Irbesartan and Hydrochlorothiazide, which is used for patients whose blood pressure cannot be effectively controlled by Irbesartan or Hydrochlorothiazide alone. Its common adverse reactions include electrolyte disorders, dizziness, nausea, and abnormal urination. It is contraindicated in patients with severe hepatic or renal dysfunction, pregnant and lactating women, and patients with allergy to the components of the drug and intractable hypokalemia. Amlodipine benzenesulfonate belongs to the calcium antagonist class of antihypertensive drugs. Common adverse reactions include headache, edema, fatigue, insomnia, nausea and palpitations. Patients who are allergic to dihydropyridines are prohibited. The above two types of drugs belong to different kinds of antihypertensive drugs, which can be replaced or combined with each other. However, whether hypertensive patients can replace Irbesartan Hydrochlorothiazide Tablets with Amlodipine Benzenesulfonate Tablets should consult with a medical professional for the application of antihypertensive drugs and the adjustment of antihypertensive drugs according to the specific conditions.