High antithyroglobulin antibodies are often seen in thyroid disorders as well as autoimmune disorders. 1. Thyroid disease: Antithyroglobulin antibodies are autoantibodies commonly used to diagnose thyroid disease. Some thyroid diseases may cause high anti-thyroglobulin antibodies, such as Hashimoto’s thyroiditis, Graves’ disease, and thyroid malignancy. 2. Autoimmune diseases: such as systemic lupus erythematosus, polymyositis, myasthenia gravis, etc. may also cause elevated anti-thyroglobulin antibodies. Generally, after the primary disease is treated, the value of anti-thyroglobulin antibodies can be normalized. Patients with elevated anti-thyroglobulin antibodies should combine with thyroid ultrasound and other tests, such as thyroid peroxidase antibodies and thyroid hormone receptor antibodies, to make a comprehensive judgment under the guidance of a doctor to identify the cause of the disease and treat the symptoms.