Male perineal itching is mainly due to local infection. The male perineum is a relatively independent and closed space, with a high density of sweat gland distribution and a large amount of sweat secretion, so it is easy to produce local heat and humidity. In the closed environment, bacteria and fungi can easily multiply, and excessive multiplication will bring clinical symptoms of local infection. Common symptoms are local itching, some patients will have skin rash, if combined with bacterial infection, there will be local redness, swelling, pain, and in serious cases, there will be ulceration, pus and other situations. For such patients should maintain the hygienic habits of bathing and changing underwear regularly, and if symptoms have appeared can use topical medications, such as erythromycin ointment, diphenhydramine spray, dacrynic ointment, etc. can be used. In addition patients should be treated with oral antibiotics for 1 week based on the use of topical drugs, commonly used drugs include quinolones, fosfomycin, cephalosporins, etc. Through systematic and standardized treatment, a better therapeutic effect can be achieved.