Many people with Parkinson’s disease experience stiffness and sudden exacerbations of the disease, and the causes of this condition vary. Life aspects and medication can affect the condition, so what can be done to address the sudden exacerbation? You can refer to the following typical case. Name: Syg Gender: Male Age: 64 years old Main reason: “7 years of bradykinesia and limb stiffness, aggravated for one day”. Case characteristics: Elderly male with 7 years of disease duration. Main clinical manifestations: slow movement, with cold wrist and ankle joints on the right side, lumbar pain, weakness of the right side of the limb, smaller and slower pace, obvious gait disorder when starting and turning, stiffness of the limb, inability to move after the effect of medication wears off, even standing still during walking due to stiffness, more irritable than before, scolding his wife, difficulty in self-care; 1 day ago, no obvious cause of general stiffness, slurred speech, difficulty in communication, inability to move. He had difficulty communicating, could not move, had panic attacks and shortness of breath, and had poor results after taking medication several times. Preliminary diagnosis: Parkinson’s disease Treatment: After admission, we actively improved the relevant examinations and preoperative evaluation, the patient’s diagnosis was clear, the indications for surgery were good, and the preoperative examinations were not contraindicated. The patient recovered well after the operation and the incision healed well. The patient was discharged from the hospital in good general condition, with clear consciousness, mental status, good diet and sleep, and good general activities. The left parietal incision healed class A/I, and the sutures were removed; the right parietal, right postauricular, and right anterior thoracic incisions were well aligned, with no redness or oozing. Discharge diagnosis: Parkinson’s disease Discharge medical advice: 1. Suggestions: regular sterilization and dressing of the surgical area and removal of sutures at the appropriate time; continue the preoperative medication regimen; psycho-psychiatric consultation and treatment of psychiatric abnormalities. 2. Health education: strengthen nutrition and physical fitness. After 1 month after surgery, you can wash your hair gently with warm water, avoid itching and scratching the wound to prevent infection.3. Follow-up time: 1 month after the follow-up consultation to turn on the regulator and follow up the discomfort. Bad sleep and fatigue can cause aggravation of symptoms, especially bad sleep is one of the important reasons for aggravation of symptoms in Parkinson’s patients. Whether the medication schedule has been adjusted, whether the dose has changed, whether the medication has been forgotten, whether the medication has been missed, as time accumulates, these are all factors that lead to aggravation of symptoms. When symptoms worsen, it is important to go to a specialist hospital as soon as possible so as not to miss the time to seek treatment.