Long-term loratadine for rhinitis may cause liver damage and other risks. 1. Loratadine is an antihistamine, mainly a common drug used to treat allergic diseases, often used in allergic rhinitis, hives and other diseases. In particular, allergic diseases can recur over a long period of time and may depend on anti-allergy medications to be taken on a regular basis. 2. The main adverse effects of loratadine may cause headache, dry mouth, occasionally jaundice, impaired liver function and other liver function abnormalities. Liver damage may be induced if the drug is not used correctly for a long period of time. For patients who have been taking it for a long time, liver function needs to be tested regularly and the drug should be stopped if necessary. 3. There are some recurrent rhinitis that can reduce the oral medication by topical nasal sprays, which can also get better results, such as mometasone furoate nasal spray. It is recommended that standardized medication and treatment be directed by a specialist after a clear diagnosis and assessment of the condition.