Stiff person syndrome is a rare disorder characterized by progressive muscle stiffness, tonus and spasticity involving the medial muscles (muscles adjacent to the cervical or lumbar spine), resulting in severely impaired walking function. It is now thought to be associated with abnormal autoimmune mechanisms and often occurs in conjunction with a number of autoimmune diseases including thyroiditis, vitiligo, pernicious anemia, and type 1 diabetes mellitus. Oral valium may be the best initial treatment option; if treatment is not effective, treatment may be changed or added to baclofen. Botox is not a cure for Stiff Person Syndrome, but it can significantly reduce the symptoms of muscle spasm, reduce pain, improve the ability to live and work, and improve sleep quality, as well as significantly relieve stiffness in the cervical or lumbar paraspinal plate-like muscles. In a typical patient with stiff person syndrome, who presents with plate-like muscle stiffness in the back, treatment focuses on the paravertebral superficial erector spinae muscles. The treatment usually requires multiple injections bilaterally; the total amount of each injection is 200-300 U. Of course, if the muscles of the neck, shoulder or extremities are involved, the treatment will be evaluated separately on a case-by-case basis. It is recommended to follow up 2 to 4 weeks after injection to assess the appropriateness of the injection protocol; the efficacy is maintained for 3 to 6 months and can be re-injected; the medication used before the injection can generally be continued and the dose can be adjusted according to the residual symptoms after the botulinum toxin takes effect; avoid factors that trigger spasm, such as sudden movement, noise or mood swings.