SPS refers to Stiff Person Syndrome, a disease of the central nervous system. The etiology includes genetic factors, neurophysiology and so on. It manifests as paroxysmal muscle pain in the abdomen, trunk and other parts of the body, with gradual onset of muscle stiffness and other symptoms. It is a central nervous system disease characterized by excessive muscle contraction of the trunk and lower limbs, accompanied by muscle pain and muscle spasm. The etiology of the disease is considered to be related to genetic factors, neurophysiology, and immune response. In the early stage of the disease, there are paroxysmal muscle pains in the abdomen, trunk and other parts of the body, which may involve the limbs and trunk, etc. The progression of the disease will result in persistent or fluctuating muscle stiffness, and the joint activities are obviously limited. Sometimes a slight stimulus can induce severe pain, severe pain in the limbs, panic and screaming. After the onset of this disease under the guidance of the doctor to symptomatic treatment.