Domperidone is not to be used in combination with potent inhibitors of the CYP3A4 enzyme, which are anticholinergics, inhibit gastric acid secretion, and cause prolongation of the QT interval. Domperidone is a gastric stimulant, which can promote gastric peristalsis, relieve nausea, vomiting, abdominal distension and other symptoms, and is often used in the treatment of dyspepsia and reflux esophagitis. When taking this product, you need to be careful not to take with some drugs at the same time, because the drugs will react with each other, some will affect the efficacy of the drug, and some will aggravate the adverse reactions. Domperidone can not be used in combination with anticholinergic drugs, and this type of drug will offset the efficacy of the combination, such as scopolamine, etc.; can not be used in combination with drugs to inhibit gastric acid secretion and antacids, such as omeprazole, etc., which will reduce the role of domperidone; can not be used in combination with diazepam or lithium, the combination of the extrapyramidal reactions may be caused. Combining domperidone with potent inhibitors of the CYP3A4 enzyme that may prolong the QT interval (an indicator of cardiac depolarization and repolarization) can lead to an increase in the blood concentration of domperidone, with clinically significant alterations in the QT interval being seen, and therefore combining the two drugs is prohibited. In addition, according to the instructions, domperidone is also prohibited in combination with oral preparations of ketoconazole and erythromycin. When taking domperidone, it is recommended to follow your doctor’s instructions and avoid self-administration.