The reason for the symptoms of sore thighs at night is as follows: 1. It may be caused by neurogenic diseases, such as lumbar disc herniation, which can lead to stimulation and compression of the sciatic nerve, causing radioactive pain in the sciatic nerve, which can cause the feeling of sore thighs at night. 2. It may be due to a long period of time without strenuous exercise and sudden strenuous activity during the day, leading to an abnormal accumulation of lactic acid in the muscles. The accumulation of lactic acid will produce acidic metabolites, which are not discharged in time to stimulate the peripheral nerves, causing the symptoms of sleeping with sore thighs at night. Therefore, the symptoms of sleeping with sore thighs at night, bed rest, avoid strenuous activities, you can give appropriate physical therapy, or local topical anti-inflammatory and analgesic drugs to relieve symptoms. If the symptoms of soreness and swelling are not relieved within a short period of time or if the condition is progressively aggravated, you must go to a regular hospital in time.