Misoprostol tablets will react within two to six hours of being placed in the vagina, with the earliest reaction occurring in about half an hour and the average time being four hours. Misoprostol tablets are a prostaglandin preparation that promotes uterine contractions and also softens the cervix, but the response time is not the same for everyone. Misoprostol tablets are usually used in conjunction with mifepristone for termination of pregnancy in early pregnancy. Mifepristone works by killing the embryo, while misoprostol tablets work by allowing the uterus to contract, the cervix to soften, and the mouth of the uterus to dilate, so that the gestational sac and embryo can be expelled. There are certain risks associated with the application of these two medications, so they should always be applied under the supervision of a physician. Mifepristone can be taken at home, but the application of Misoprostol tablets must be followed by a hospital stay, where the doctor will observe the amount of vaginal bleeding and the complete expulsion of the pregnancy sac.