Antibiotics are preferred for the treatment of pyelonephritis, and the more common ones are quinolones, semi-synthetic penicillins and cephalosporins, which usually have better effects on the treatment of chronic nephritis. Pyelonephritis is a disease caused by infection by pathogens such as Escherichia coli, and drugs that are effective against gram-negative bacilli are preferred, so the treatment drugs are mainly a variety of antibiotics, and some of the more common antibiotics are quinolones (oxfloxacin, levofloxacin, and ciprofloxacin), semisynthetic penicillins (amoxicillin), and cephalosporins (cefuroxime), and so on. If the treatment of pyelonephritis is effective for 72 hours, there is no need to change the medicine, otherwise the antibiotic should be changed according to the result of drug sensitivity. If the patient’s urinary frequency, urgency, and urinary pain symptoms are more obvious, you can also take Chinese medicines such as Sanjin Tablets and Heat Lymph Qing to improve the symptoms. Various antibiotics such as semi-synthetic penicillins and cephalosporin antibiotics may cause allergic reactions, and quinolones may cause chondrodysplasia. Therefore, pyelonephritis drugs need to be applied under the guidance of specialists, and cannot be used on their own.