To date, the exact cause of Parkinson’s disease is not well understood, and therefore, preventive measures lack precise targeting. However, many studies have confirmed that there is a causal relationship between many of the risk factors mentioned above and the degeneration and necrosis of dopamine neurons in the substantia nigra of the midbrain, and if corresponding preventive measures can be taken against the risk factors, it is certainly beneficial to prevent the onset of Parkinson’s disease and slow down the progression of the disease. Primary prevention (no disease prevention) 1, the family history of Parkinson’s disease and related gene carriers, toxic chemical exposure, should be regarded as a high-risk groups, close supervision and follow-up, regular physical examination, and strengthen health education, pay attention to self-protection. 2, increase the efforts of industrial and agricultural production of environmental protection, reduce the emission of harmful gases, sewage, dirt, harmful workers should strengthen labor protection. 3.Improve the drinking water facilities in rural areas and towns, protect water resources, reduce the pollution of river water, reservoir water, pond water and well water, and ensure that the general public can drink safe and healthy drinking water. 4.The elderly should be careful with phenothiazines, reserpine and butylphenolic drugs. 5, pay attention to the prevention and treatment of geriatric diseases (hypertension, hyperlipidemia, hyperglycemia, cerebral atherosclerosis, etc.), enhance physical fitness, slow down aging, prevent atherosclerosis, can play a positive role in the prevention of Parkinson’s disease. Secondary prevention (early detection, early diagnosis, early treatment) 1, early diagnosis. The subclinical phase of Parkinson’s disease is long. If preclinical diagnostic techniques such as olfactory dysfunction, PET scan, mitochondrial DNA, dopamine antibodies, cerebrospinal fluid chemistry, electrophysiology, etc. can be carried out immediately, the subclinical phase of Parkinson’s disease can be detected early and treated with neuroprotective agents (such as vitamin E, SOD, glutathione and glutathione peroxidase, neurotrophic factor, celebrex), which may will delay the entire course of the clinical phase. 2, early Parkinson’s disease, although the nigrostriatal and striatal nerve cells are reduced, but dopamine secretion is compensatory increase, at this time the brain dopamine content is not significantly reduced, called compensatory period, generally do not advocate drug treatment, can be used physical therapy, medical sports, tai chi, hydrotherapy, massage, qigong, acupuncture and other treatments to maintain the general daily work and life, as far as possible to postpone the application of anti-tremor paralysis drugs. However, some people advocate the early application of small doses of levodopa to reduce complications, which should be selected on a merit basis depending on the individual. 3, Parkinson’s disease decompensated phase should be treated with drugs. Tertiary prevention (delay the development of the disease, prevent disability, improve the quality of life) 1, active non-drug such as physical therapy, body therapy, acupuncture, massage, and Chinese and Western medicine or surgery and other comprehensive treatment to delay the development of the disease. 2, pay attention to psychological guidance and comfort and spiritual care, ensure sufficient sleep, avoid emotional tension and excitement, in order to reduce the triggering factors for the aggravation of myocardial tremor. 3.Actively encourage patients to take the initiative to exercise, such as eating, dressing, washing, etc. For those who have speech disorders, practice pronunciation loudly and diligently in front of the mirror. Strengthen joint and muscle activities and labor training, maintain the motor function of the limbs as much as possible, and pay attention to prevent falls and limb deformities from being disabled. 4, long-term bedridden people, should strengthen life care, pay attention to cleanliness and hygiene, turn and pat the back regularly to prevent complications such as pneumonia and bed sores infection, Parkinson’s disease most of the deaths from lung or other systems such as urinary system infections. Pay attention to diet and nutrition, nasal feeding if necessary, and keep the bowels open. To constantly strengthen the body, improve immune function and reduce mortality.