Mature red blood cells cannot perform aerobic respiration because aerobic respiration requires the participation of various organelles, especially mitochondria, in order for the cell to perform aerobic respiration. However, mature erythrocytes do not have a nucleus or organelles, which means that there are no mitochondria in the erythrocyte, so they cannot participate in aerobic respiration. Erythrocytes cannot perform aerobic respiration, but erythrocyte energy supply is mainly accomplished through anaerobic glycolysis. To complete anaerobic glycolysis, enzymes are required, including glucose-6-phosphate dehydrogenase and pyruvate kinase, which are necessary for anaerobic glycolysis in erythrocytes. If the activity of these enzymes decreases or is absent, erythrocytes cannot undergo anaerobic glycolysis, red blood cells cannot receive sufficient energy supply, and patients will experience a series of symptoms, the most likely of which is hemolytic anemia. One of them is sericosis, which is caused by a decrease in glucose-6-phosphate dehydrogenase activity, so that mature red blood cells cannot perform aerobic respiration and can only perform anaerobic glycolysis.