Graphical disorientation means that the patient cannot distinguish the specific place where he or she is, such as thinking a hospital is his or her home or a factory is a school, which is a typical symptom of Alzheimer’s disease. So how to self-examine the graphic orientation disorder? First, the onset of the disease is insidious, the course of the disease is irreversible progression There is often no exact time of onset and symptoms of the disease, early often not easily detected, once it occurs, it is irreversible slow progress. Second, the core symptoms of Alzheimer’s disease 1, memory impairment for the first symptoms of Alzheimer’s disease. There is both amnesia and forgetfulness. Amnesia refers to the defect of remembering new knowledge, which is related to cortical dysfunction; amnesia refers to the defect of distant memory, i.e., the low ability to recall information already remembered in the past, which is related to subcortical dysfunction. The initial appearance is impaired near memory, followed by impairment of distant memory eventually both distant and near memory are impaired. 2. Cognitive impairment refers to the ability to acquire and apply knowledge. It includes verbal and nonverbal skills, the ability to remember new knowledge and the ability to recall knowledge from a rich knowledge base. Cognitive dysfunction is decisive for the diagnosis of dementia. Non-verbal cognitive dysfunction occurs more rapidly and earlier than the onset of verbal impairment. Early in the course of AD, there can be miscalculation, poor judgment, loss of generalization, distractibility, and left-right disorientation that becomes more pronounced as the disease progresses. 3.Aphasia Language change is a sensitive indicator of cortical dysfunction. Aphasia is a common characteristic symptom of AD and is not common in other causes of dementia. Oral comprehension is progressively impaired, repetition is relatively preserved until late in life, and syntax and articulation are relatively preserved until late in life, while semantic aspects are progressively impaired. It may manifest as word finding difficulties, redundant spontaneous speech, naming inability, glazed aphasia, and progressively more pronounced misophonia. Referring to the middle and late stages of the disease, there can be a variety of distinctive repetitive speech disorders, such as: imitative language, for the patient to repeat words and phrases spoken to him or her by the examiner. Repetitive speech disorder, as the patient repeats words and phrases that he or she has said; word ending repetition disorder, as the patient repeats the last part of the word. In late stages, dysarthria (unintelligible sounds) and even muteness (mute speech) appear. Visuospatial skill impairment, loss of recognition and loss of use Early in AD, visuospatial skills are impaired and are more severe than in other types of dementia. For example, they are unable to copy shapes, do structural work, connect tests and arrange blocks and puzzles. Nearly 1/3 of AD patients have visual loss, face loss, body image impairment, visuospatial loss, geographic disorientation, etc., which worsen as the disease progresses. The accompanying symptoms of Alzheimer’s disease Psychotic symptoms are the accompanying symptoms of AD. They are reduced initiative, indifference or loss of control of emotion, depression, restlessness, excitement or euphoria, insomnia, hallucinations (hearing, seeing), delusions (murdered, stolen, jealous delusions, etc.), wandering, meaningless hyperactivity, self-talk or loud talking, agitation, impure behavior, aggressive tendency, etc. These symptoms are often the purpose of patients with AD seeking treatment and should not be ignored in the diagnosis of dementia.