Graphic disorientation is a symptom of having Alzheimer’s disease. Alzheimer’s disease (AD) is a progressive and evolving neurodegenerative disorder with insidious onset. It is characterized by memory impairment, aphasia, dysarthria, dyscognition, visuospatial skills impairment, executive dysfunction, and personality and behavioral changes, and the cause of the disease is still unknown. those who develop the disease before the age of 65 years old are called early-onset dementia, and those who develop the disease after the age of 65 years old are called Alzheimer’s disease. What are the tests for graphic orientation disorder? 1.Laboratory tests As part of the evaluation of dementia, it is indispensable to determine the cause of dementia and common coexisting diseases among the elderly. Thyroid function tests and serum vitamin B12 levels are necessary to determine other specific causes of dementia, and the following tests should also be performed: complete blood count; blood urea nitrogen, serum electrolytes and blood glucose levels; liver function test 15 When the history or clinical situation suggests that the cause of dementia may be an infection, an inflammatory disease, or exposure to a toxic substance, the following special laboratory tests should be performed: syphilis serology, blood sedimentation, human immunodeficiency virus (HIV) antibody testing, or heavy metal screening. 2.Enzyme-linked immunosorbent assay (ELISA) sandwich assay Detect AD patients’ cerebrospinal fluid tau protein, AB protein, biochemical testing CSF dopamine, norepinephrine, 5-HT and other neurotransmitters and metabolites level changes. 3, PCR-RFLP technology Detection of APP, PS-1 and PS-2 gene mutations can help to confirm the diagnosis of early-onset familial AD, Apo E4 gene significantly increased carriers may be sporadic AD patients, but these indicators can not be used as a clinical diagnosis of the disease. 4, Determination of Apo E phenotype ApoE polymorphism is an important determinant of the risk of Alzheimer’s disease (AD), Shimaro et al. (1989) first described the relationship between AD and ε4, and they found that the frequency of ε4 in patients with AD was 2-fold higher than that in the control group by using the IEF study, since then, Rose’s group and others reported that ε4 frequency was increased in patients with delayed onset familial AD (FAD), and all these studies described that ε4 frequency was increased in patients with early onset familial AD. These studies have described, confirmed and discussed the relationship between ε4 and AD. Schachter et al. (1994) were the first to report that centenarians commonly carry the ε2 allele, and that the number of ε2s carried by elderly people is twice as many as that of young people. Therefore, the ε2 gene seems to not only protect people from AD, but also to be associated with longevity. 5.Electroencephalography In the EEG topography of AD patients, the delta and theta power are enhanced diffusely and symmetrically, and the alpha power is decreased in most regions.